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In their Letter to Molecular Biology of the Cell, Schmoller et al. (2022) raise questions about the results and conclusions presented in our published studies (Dorsey et al., 2018; Litsios et al., 2019). Here, we respond to the criticisms of Schmoller et al. and demonstrate how wide-field fluorescence microscopy experiments to determine nuclear Whi5 concentration dynamics can be confounded by uncontrolled effects, which include photobleaching, partial confocal effects, and nuclear-to-cytoplasmic volume scaling. Further, we provide additional experimental evidence demonstrating that nuclear Whi5 concentration is essentially constant as cells grow in G1 phase and that Cln3 and protein synthesis dynamics occur as reported in Litsios et al. (2019). These results suggest that instead of being triggered by dilution of the stable inhibitor Whi5, Start is rather primarily controlled by the increase in protein synthesis rate in G1 and the concomitant production of the unstable activator Cln3. 

We report the discovery and characterization of two small transiting planets orbiting the bright M3.0V star TOI-1468 (LSPM J0106+1913), whose transit signals were detected in the photometric time series in three sectors of the TESS mission. We confirm the planetary nature of both of them using precise radial velocity measurements from the CARMENES and MAROON-X spectrographs, and supplement them with ground-based transit photometry. A joint analysis of all these data reveals that the shorter-period planet, TOI-1468 b ( P b = 1.88 d), has a planetary mass of M b = 3.21 ± 0.24 M ⊕ and a radius of R b = 1.280 −0.039 +0.038 R ⊕ , resulting in a density of ρ b = 8.39 −0.92 +1.05 g cm −3 , which is consistent with a mostly rocky composition. For the outer planet, TOI-1468 c ( P c = 15.53 d), we derive a mass of M c = 6.64 −0.68 +0.67 M ⊕ ,aradius of R c = 2.06 ± 0.04 R ⊕ , and a bulk density of ρ c = 2.00 −0.19 +0.21 g cm −3 , which corresponds to a rocky core composition with a H/He gas envelope. These planets are located on opposite sides of the radius valley, making our system an interesting discovery as there are only a handful of other systems with the same properties. This discovery can further help determine a more precise location of the radius valley for small planets around M dwarfs and, therefore, shed more light on planet formation and evolution scenarios. 

We report the discovery and confirmation of the planetary system TOI-1288. This late G dwarf harbours two planets: TOI-1288 b and TOI-1288 c. We combine TESS space-borne and ground-based transit photometry with HARPS-N and HIRES high-precision Doppler measurements, which we use to constrain the masses of both planets in the system and the radius of planet b. TOI-1288 b has a period of $2.699835^{+0.000004}_{-0.000003}$ d, a radius of 5.24 ± 0.09 R⊕, and a mass of 42 ± 3 M⊕, making this planet a hot transiting super-Neptune situated right in the Neptunian desert. This desert refers to a paucity of Neptune-sized planets on short period orbits. Our 2.4-yr-long Doppler monitoring of TOI-1288 revealed the presence of a Saturn–mass planet on a moderately eccentric orbit ($0.13^{+0.07}_{-0.09}$) with a minimum mass of 84 ± 7 M⊕ and a period of $443^{+11}_{-13}$ d. The five sectors worth of TESS data do not cover our expected mid-transit time for TOI-1288 c, and we do not detect a transit for this planet in these sectors.